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KMID : 0895420130230030266
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Journal of Korean Society of Occupational and Enviromental Hygiene
2013 Volume.23 No. 3 p.266 ~ p.272
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Influence of Chronic Low-Level Exposure to Toluene on Cell-Mediated Immunity
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Jang Seung-Hee
Choi Yoon-Jung
Kim Ki-Woong
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Abstract
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Objectives: This study aimed to evaluate the effects of low-level exposure to toluene on T lymphocytes subpopulations.s.
Methods: The study lasted from April to October 2010. The subjects were 390 male workers, among whom 137 were chronically exposed to toluene in video-tape manufacturing factories and 253 were controls had never been occupationally exposed to hazardous chemicals. The subpoupulations of CD4+, CD8+, CD16+(Natural killer cells) and total(CD3+) T lymphocytes were examined by two-color staining using monoclonal antibodies. The general and job characteristics of subjects were assessed through a self-administered questionnaire.
Results: There was no significant difference in general and job characteristics between both groups. No significant difference in lipid peroxide level was observed between the control and exposed workers, but the concentration of hydrogen peroxide was significantly higher in the exposed workers. The numbers of CD16+ T lymphocytes in controls were significantly higher than those in exposed workers, but no significant differences were found in CD4+, CD8+ and CD3+ T lymphocytes. Hydrogen peroxide levels showed a significantly negative correlation with CD8+(r = -0.29, p < 0.01), CD16+(r = -0.56, p < 0.01) and CD3+(r = -0.22. p < 0.01), and toluene levels was significantly negative correlated with CD3+(r = -0.29, p < 0.05).
Conclusions: Our results suggest that chronic low-level exposure to toluene affects cell-mediated immunity and the effects might mediate through ROSs(Reactive Oxygen Species) such as hydrogen peroxide.
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KEYWORD
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Toluene, T lymphocytes subpopulations, ROSs, Workers
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